Making Downstream Bioprocessing More Efficient, Cost-Effective

Downstream Bioprocessing

Downstream bioprocessing is a critical phase in the production of biopharmaceuticals, involving the purification and refinement of biological products to ensure they meet the necessary quality and safety standards for therapeutic use. These products include plasmids, mRNA, oligos, cell and gene therapies, antibody variants, and vaccines. Making downstream bioprocessing more efficient and cost-effective while ensuring high-quality outputs for biopharmaceutical production is a key objective. To achieve this, BioInnovas offers extensive downstream processing solutions from emp Biotech, focusing on chromatography techniques tailored for both clarified and unclarified feed streams. Our approach centers on enhancing process efficiency, scalability, and environmental sustainability.

Key Purification Stages in Downstream Bioprocessing and emp Biotech Products

Clarification

Clarification removes cell debris and particulate matter, preventing clogging and ensuring efficiency in subsequent steps. Simplify this process with emp BIOTECHs SMART Chromatography™, which integrates clarification and primary capture into one operation, reducing costs and maintaining high product quality. SMART Chromatography™ removes the bottleneck in your downstream process by allowing the purification of biomolecules directly from the bioreactor without first having to clarify the feed stream. It offers linear scalability, significantly reduces costs and processing time, and can be used for various cell systems.

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Capture Chromatography

Capture chromatography isolates the target biomolecule from the feed stream, ensuring its initial concentration. Enhance this step with emp BIOTECHs Zetarose Affinity Resins, which offer high binding capacities and are ideal for repeated purification cycles, ensuring cost-effectiveness and high yields.

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Intermediate Purification

Intermediate purification removes bulk impurities, enhancing product purity. Achieve this with emp BIOTECHs Zetarose Ion Exchange Resins, which provide robust platforms for high purity and recovery rates, making them ideal for this critical step.

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Polishing

Polishing ensures the final product meets quality and safety standards through high-resolution purification. emp BIOTECHs Size Exclusion Chromatography (SEC) Resins, such as Zetadex and Zetarose, are perfect for achieving the desired product purity and quality in this final step.

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Desalting and Buffer Exchange

Desalting and buffer exchange are crucial for removing small molecules and preparing the product for final formulation. emp BIOTECHs CentriPure Columns are ideal for efficient desalting and buffer exchange, providing high resolution and selectivity to ensure the final product’s stability and quality.

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Concentration and Formulation

Concentration and formulation involve concentrating the purified biomolecule and ensuring its stability. Use emp BIOTECHs CentriPure Columns for efficient desalting and buffer exchange, providing high resolution and selectivity to guarantee high-quality final products.