CHF 0.00
Alkylation of the N3-position of thymidine by acrylnitrile, which is liberated during ß-elimination of the cyanoethyl group from the phosphates, is a well-known side reaction during simultaneous cleavage of the protecting groups and the oligonucleotide from the support.
This side reaction can be avoided by use of diethylamine or t-butylamine in acetonitrile for the ß-elimination. The oligonucleotide is subsequently cleaved from the support using any standard cleavage conditions.
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Flammable liquid, Category 2 (Flam. Liq. 2)
Acute Toxicity, Category 4 (Acute Tox. 4)
Skin corrosion, Category 1A (Skin Corr. 1A)
Specific target organ toxicity – single exposure, Category 3 (STOT SE 3)
H225: Highly flammable liquid and vapour.
H302+H312+H332: Harmful if swallowed, in contact with skin or if inhaled.
H314: Causes severe skin burns and eye damage.
H335: May cause respiratory irritation.
P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P310: Immediately call a POISON CENTER/doctor/…
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Danger
WGK 2
3 – Flammable liquids
ADR, RID (road and rail): UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II
IATA-DGR (air transport): UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II
IMDG Code (sea transport): UN2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S. (Solution of 20% Diethylamine in Acetonitrile), 3(8), II