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AF-0202

AF-0202

CHF 0.00

Monocarboxymethylene Blue NHS ester (MCMB-SE)

Amine-reactive methylene blue redox marker for electro-active labeling, designed especially for labeling of biomolecules.

SKU: AF-0202 Categories: , , , ,

Description

Monocarboxymethylene Blue NHS Ester (MCMB-SE) – Electroactive Redox Label for Bioconjugation

AF-0202 Monocarboxymethylene Blue NHS ester (MCMB-SE) is an amine-reactive, electroactive labeling reagent designed for covalent attachment to biomolecules via primary amines. Featuring a single activated carboxylic acid, this methylene blue derivative combines strong absorbance with validated redox properties and singlet oxygen generation, making it ideal for electrochemical and photosensitizer-based applications.

Performance Highlights

  • Amine-reactive NHS ester enables stable covalent conjugation

  • Formal electrode potential: Ef = −0.198 V vs. Ag/AgCl (1 M KCl)

  • High extinction coefficient and efficient singlet oxygen generation

  • Absorption and emission maxima: 665 ± 3 nm / 670 ± 3 nm

  • Optimized for electrochemical biosensors and photodynamic labeling

Properties

  • Trade Names: Monocarboxymethylene blue NHS ester, Methylene blue succinimidyl ester

  • Reactive Moiety: NHS ester, reacts with 1° amines to form a stable amide linkage

  • Molecular Weight: 538.96

  • Empirical Formula: C₂₂H₂₃N₄O₈SCl

  • ε [M⁻¹ cm⁻¹]: >81,000

  • Solubility: Acetonitrile

  • Appearance (color): Dark blue

  • Appearance (form): Solid (powder)

  • Storage: –20 °C. Keep dry and protect from light, especially in solution

  • CAS Number: None known

Application

  • Electrochemical biosensor development

  • Redox-based detection in diagnostic systems

  • Singlet oxygen generation in photodynamic labeling

Additional information

Pack Size

, ,

Safety Information

Hazard Classifications

  • Acute toxicity, Category 4 (Acute Tox. 4)

  • Skin irritation, Category 2 (Skin Irrit. 2)

  • Eye irritation, Category 2 (Eye Irrit. 2)

  • Specific target organ toxicity – single exposure, Category 3 (STOT SE 3)

Hazard Statements

H302 – Harmful if swallowed.

H315 – Causes skin irritation.

H319 – Causes serious eye irritation.

H335 – May cause respiratory irritation.

Precautionary Statements

P261 – Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338 – IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Signal Word

Warning

WGK

WGK 3

Storage Class Code

  • 10 – Flammable liquids if not LGK 3A or 3B

  • 11 – Flammable solids

  • 12 – Non-flammable liquids in non-flammable packages

  • 13 – Non-flammable solids in non-flammable package

Transport Information

ADR / RID (Road & Rail): Not dangerous goods

IATA-DGR (Air Transport): Not dangerous goods

IMDG Code (Sea Transport): Not dangerous goods

Downloads

Material safety data sheet

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